BERLIN—Gunmen killed eight people Wednesday night in shootings in central Germany that have left police guessing about the motive and the number of shooters, who remain at large, police said early Thursday.

The attacks took place around 10 p.m. local time when the gunmen opened fire on patrons of a hookah lounge in downtown Hanau, near Frankfurt, and then fled in a dark vehicle, police said. They later resumed shooting in another part of town.

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