Stock futures fell slightly on Tuesday after the market scored its best session in six weeks a day earlier on rising optimism about a coronavirus vaccine. A drop in shares of Home Depot, which reported declining earning due to the coronavirus, weighed on sentiment.

Futures on the Dow Jones Industrial Average implied an opening loss of about 65 points, after moving more than 200 points higher in after-hours trading Monday. Dow Futures were lower by 52 points, or 0.2%. S&P 500 futures were off by 0.2%. Nasdaq 100 futures were flat.

The action followed a strong rally on Wall Street that saw the Dow and S&P 500 both enjoying their biggest one-day gains since April 6. Investors cheered news that an experimental coronavirus vaccine from Moderna showed promising early signs. The 30-stock Dow jumped more than 900 points, while the S&P 500 closed the day up 3.2%, hitting its highest level since March 6.

Home Depot shares lost about 2% in premarket trading Tuesday after the home improvement retailer said net income last quarter dropped 10.7% due to extra costs related to the pandemic. Although the retailer also said sales increased by 7% for the period.

Meanwhile, Walmart shares gained more than 3% in premarket trading after the retailer reported soaring e-commerce sales in the first quarter.

Futures cut their losses a bit after Walmart’s report.

On Monday, stocks that would benefit from re-opening the economy led the market higher. Cruise operator Carnival gained 15.2%, while Delta and United Airlines both popped more than 13%.

“With over 100 treatments and vaccines under development, a medical breakthrough, a more sophisticated test and trace model, and government support could drive more upside,” Mark Haefele, chief investment officer at UBS Global Wealth Management. “But our downside scenario cannot be ruled out. This could be triggered by a significant second wave of virus cases breaking out.”

With Monday’s gains, the S&P 500 has rebounded 32% from its March 23 low, now sitting about 13% below its record high in February.

On Tuesday, Federal Reserve Chairman Jerome Powell and Treasury Secretary Steven Mnuchin will testify virtually before the Senate Committee on Banking, Housing, and Urban Affairs in the first required update to Congress on the economic response to the coronavirus pandemic. 

Powell is expected to reiterate the central bank’s commitment to using its “full range of tools” aimed at keeping markets functioning and getting money to those in need.

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