BEIJING—China challenged U.S. Secretary of State Mike Pompeo to present evidence that would back his recent claim that the new coronavirus came from a Chinese laboratory.

The comment by Chinese Foreign Ministry spokeswoman Hua Chunying was the first official Chinese government reaction to Mr. Pompeo’s statement. It was the latest effort by Beijing to counter the Trump administration’s moves to blame China for the virus outbreak that has infected more than 3.6 million people world-wide.

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