MARIPOSA, Calif.—When Yosemite National Park finally reopened in June after a nearly three-month closure because of the coronavirus pandemic, Bryan Imrie was both relieved and nervous.

The 49-year-old, who co-owns an attraction that features a zip line and horseback rides, wanted to start making money again from his family’s business that draws tourists visiting the park. But he has had his spleen removed and suffers from an immune-compromised system.

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